Withstands rigorous CIP and sanitization procedures with NA.1 to NA.5 M NaOH. Novel ligand design gives enhanced protease resistance resulting in lower ligand leakage. Oriented coupling of recombinant Protein A to the matrix via an engineered Cterminal cysteine enhances IgG binding capacity. Fewer regulatory concerns due to the total absence of mammalian culture in the ligand production and purification. Prepacked HiTrap columns for process development, screening of purification conditions, and small scale purification of Mabs. HiTrap MabSelect columns are prepacked with MabSelect a bioprocess medium for capuring of Mabs from large sample volumes. The novel alkalitolerant recombinant Protein A ligand allow cleaninginplace (CIP).
