Costefficient at low resin utilization, such as in clinical manufacturing. Highest DBC of any of our MabSelect SuRe™ resins Alkalinestable, wellestablished protein A ligand, from the MabSelect SuRe resin, is stable when cleaned with 0.1 M NaOH for 200 cycles and approximately 100 cycles using 0.5 M NaOH. Excellent for use in short bed heights and rapid resin cycling mode to further improve productivity in protein A step. MabSelect™ SuRe 70 protein A resin with high dynamic binding capacity (DBC), enables highly costefficient capture of monoclonal antibodies (mAbs). The resin uses the wellestablished SuRe protein A ligand with good alkaline stability providing stable processing of mAbs. DBC at different residence times The MabSelect™ SuRe 70 resin is based on a highflow agarose base matrix with an average bead size of 50 μm. The optimized porosity enables a fast uptake of mAb, and the DBC is less dependent on residence time (RT) compared to other resins (e.g., MabSelect SuRe™ LX and MabSelect PrismA™ resins). The DBC for trastuzumab is higher than 70 g/L in a wellpacked column at 6 min RT. Alkalinestable protein A ligand As native protein A is sensitive to alkaline conditions, the ligand in MabSelect™ SuRe 70 resin, also used in the MabSelect SuRe™ resin, has been stabilized by engineering one of the IgGbinding domains of protein A. The MabSelect™ SuRe 70 resin is stable when cleaned with 0.1 M NaOH for 200 cycles and approximately 100 cycles using 0.5 M NaOH without performance loss. Cytiva’s mAb toolbox Process volumes, number of batches, target molecule, impurity profile, and cleaning protocols influence which chromatography resin will be most costefficient and productive in a given application. Cytiva can support you in a discussion about how to set up your process and to make your process more cost efficient. And with every Cytiva resin you choose, you have Cytiva quality, an extensive security of supply program, and expertise to go along with it.
