Fast, reliable ease of use format for small scale purification of antibodies or enrichment of proteins of interest in prepacked 96well filter plates that are ready to use. Flexible format, protocol for classical elution as well as crosslinking method. Formatted for elution for electrophoresis or LCMS analysis workflows. Fast binding kinetics and high capacity provides high yield. Easy scale up with HiTrap Protein G HP prepacked columns. Prepacked with Protein G Sepharose High Performance for coupling of antibodies of IgG subclasses. MultiTrap 96well filter plates can be used with centrifugation or vacuum, manually or in automated robotic systems. Protein G Sepharose HP has high affinity for the Fc region of IgG from a variety of species. The two options in the protein enrichment protocol allow the attached antigen to be eluted separately (crosslink protocol) or together with the antibody (classic protocol) A protocol for efficient, small scale purification of monoclonal and polyclonal antibodies from serum and cell culture supernatants in less than 2NA min is also provided. No pretreatment of the sample is required